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需要指出的是，对于轴突的珍珠状，科学家们其实并不陌生。早在半个世纪前，就有研究发现在遭受神经系统疾病或是面临压力时，轴突会收缩成珍珠状，这样的改变可以避免细胞损伤的扩散。此外，即使是正常神经元的轴突，在细胞核物质运输进出受阻时，也可以暂时膨大形成囊泡。但不同的是，这些“珍珠”都属于宏观尺度；而在最新研究中，以纳米尺度均匀分布的“珍珠串”是首次发现，并且是正常神经元轴突所共有的。
轴突中含有轴向细胞骨架，负责将合成于神经元胞体内、含有神经递质的囊泡运输到轴突末端的突触前膜。
近年来，有研究利用冷冻保存技术，在线虫与栉水母中也观测到了类似的纳米尺度珍珠状轴突。因此论文指出这种珍珠形态在物种间高度保守，是轴突普遍存在的特征。
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